Updated regularly · All 50 states

Naloxone, near you.
Free or low-cost — in every state.

Pick your state to see the fastest way to get it, what it costs, where to go, and what the law actually protects.

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Naloxone in Mississippi

UNKNOWNGood Samaritan law: yesVerified

Your fastest option

NEXT Distro or MS Harm Reduction.

At a pharmacy

How it's dispensed
Standing order (voluntary participation).
Medicaid
Covered.
Typical cost
OTC ~$45

Free by mail

Local programs

What the Good Samaritan law actually covers

Narrow: very small amounts only.

Known barriers & workarounds

Pharmacy refusal common; mail order reliable.

If someone is overdosing right now

Four calm steps.

  1. 1

    Call 911.

    Say "I think this is an opioid overdose." Stay on the line. The Good Samaritan law in almost every state protects you — you can see yours above.

  2. 2

    Give one spray of naloxone in one nostril.

    Tilt their head back. Insert the nozzle. Press the plunger all the way down. That is the full dose — do not prime it first.

  3. 3

    If no response in 2–3 minutes, give another spray.

    Use the other nostril. Fentanyl overdoses often need two doses. It's safe to give more.

  4. 4

    Lay them on their side and wait with them.

    This is the recovery position. It keeps their airway clear. Stay until paramedics arrive.

Naloxone cannot hurt someone who isn't on opioids. If you are unsure, give it anyway.

About naloxone

A medicine that gives someone their breath back.

Naloxone — often sold as Narcan — is a nasal spray that reverses an opioid overdose within minutes. It works on heroin, fentanyl, oxycodone, methadone, and every other opioid. It does nothing to people who don't have opioids in their system, which is why it's safe to carry and safe to use when you aren't sure.

In 2023 the FDA made it available over the counter. You do not need a prescription, an ID, or a reason. You do not need to explain yourself at the pharmacy counter. One box holds two doses.

Carrying naloxone is not a sign that something is wrong in your life. It is the same reason people learn CPR: because the minutes before an ambulance arrives are the minutes that matter.

What it costs

Three honest facts about price.

  • Free — almost every state health department and harm-reduction nonprofit will mail you a kit at no charge. Many do not ask for your name.
  • $0 with Medicaid — every state's Medicaid program covers naloxone, usually with no copay.
  • $45–65 over the counter — the pharmacy price without insurance. It is the most expensive way to get it.

Common questions

Straight answers.

Do I need a prescription?

No. Naloxone nasal spray is over the counter at every major pharmacy chain.

Will I get arrested if I call 911?

Almost certainly not. Every state except Kansas and South Dakota has a Good Samaritan law. The details vary — select your state above to see exactly what's protected.

Does it work on fentanyl?

Yes. Fentanyl is stronger, so strong overdoses sometimes need a second dose two to three minutes after the first. Call 911 first, give naloxone, give another if they don't respond.

What if I give it to someone who isn't overdosing?

Nothing happens. Naloxone only affects opioids. If they aren't on opioids, it will not hurt them.

Does it expire?

Yes, but most states' Good Samaritan laws protect you even if you use expired naloxone. Expired naloxone is still better than no naloxone.

I don't use opioids. Should I carry it?

Yes, if you can. Most overdoses happen in front of someone who isn't using. Keep one kit at home and one in your bag. Teach the people you live with.